Ulcerative colitis is more localized in nature than Crohn’s disease. Typically, the disease affects the colon (large bowel) including the rectum and anus, and only invades the inner lining of bowel tissue. It almost always starts at the rectum, extending upwards in a continuous manner through the colon. Colitis can be controlled with medication and in severe cases can even be “cured” by surgical removal of the entire large intestine.
The purpose of this research study is to evaluate the safety and efficacy of Ustekinumab (Stelera) Induction and maintenance therapy in subjects with moderately to severely active ulcerative colitis.